CORDIS Project
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This project investigates the role of T-cells in the pathogenesis of neurodegenerative diseases, specifically focusing on amyotrophic lateral sclerosis and frontotemporal dementia. It aims to understand how immune responses contribute to disease mechanisms and identify potential therapeutic targets.
Neurodegenerative diseases are the top 3 leading causes of death and are viewed now as systemic diseases.
Adaptive immunity including a T-cell response in the central nervous system (CNS) likely contributes to disease pathogenesis.
How T cells are primed and recruited to CNS is largely unexplored, due to the complexity of the process and lack of tools and animal models. I will study these questions on the most common genetic form of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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