CORDIS Project
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This project focuses on understanding DNA-protein crosslinks (DPCs) and their repair mechanisms, which are crucial for maintaining genome stability. By exploring the role of specific proteases in DPC repair, the project aims to uncover new pathways that could lead to novel cancer therapies.
This project aims to address the most pressing questions in the emerging field of research on DNA-protein crosslinks (DPCs) and their repair.
Covalent DPCs are highly toxic DNA lesions that block virtually all chromatin processes. DPCs are induced by various exogenous and endogenous agents, but dedicated repair mechanisms were unknown.
It was previously assumed that DPCs are repaired by canonical DNA repair pathways.
This has changed with my recent discovery of a specific and conserved DPC repai…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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