CORDIS Project
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This project investigates the role of DNA methylation in acute myeloid leukaemia, focusing on the enzyme TET2 and its impact on gene regulation. By studying mouse models, it aims to identify how altered DNA methylation contributes to cancer development and potential therapeutic targets.
Acute myeloid leukaemia (AML) is an aggressive type of blood cancer characterized by uncontrollable growth of immature myeloid cells.
Somatic mutations in diverse transcriptional regulators result in aberrant epigenetic landscape in leukemic cells, including patterns of DNA methylation.
Due to its reversible nature, this epigenetic mark has been a promising therapeutic target and DNA methyltransferase inhibitors are already being used with varying degrees of success in clinic.
The targeted impro…
KOBENHAVNS UNIVERSITET
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