CORDIS Project
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The project aims to enhance nuclear magnetic resonance crystallography techniques for studying organic molecular solids, particularly nucleic acids. It seeks to address challenges in characterizing these biological materials due to their complex interactions with water and metal ions.
The goal of this proposal is to develop efficient strategies for the nuclear magnetic resonance (NMR) crystallography of organic molecular solids, focussing on nucleic acids and their derivatives.
These systems are natural targets for the developing field of crystallography via NMR since H-bonding and tautomerism are central to their biological activity.
The structure and function of RNA and DNA depends strongly on associated metal ions and with water molecules, but the non-covalent and dynamic…
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