CORDIS Project
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This project investigates the role of a novel protein family in regulating DNA methylation patterns, particularly focusing on TET proteins that convert 5-methyl-cytosine to 5-hydroxymethyl cytosine. The research aims to understand their function in normal blood cell development and their implications in hematological c…
DNA methylation patterns are frequently perturbed in human diseases such as imprinting disorders and cancer.
In cancer increased aberrant DNA methylation is believed to work as a silencing mechanism for tumor suppressor genes such as INK4A, RB1 and MLH1.
The high frequency of abnormal DNA methylation found in cancer might be due to the inactivation of a proofreading and/or fidelity system regulating the correct patterns of DNA methylation.
Currently we have very limited knowledge about such mech…
KOBENHAVNS UNIVERSITET
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