CORDIS Project
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This research focuses on advancing spatial transcriptomics to better understand gene regulation during embryonic development. By developing a novel DNA microscopy technique, the project aims to achieve high-resolution mapping of RNA and proteins, facilitating insights into cellular processes and interactions in develop…
New tools are needed in spatial transcriptomics, which uses imaging to resolve the positions of RNA in their native biological contexts to reveal molecular mechanisms underlying cell states and interactions.
The developing embryo exhibits complex transcriptional regulation during the maternal-to-zygotic transition, when the reservoir of maternal RNA is phased out and the zygotic genes are turned on.
Existing spatial sequencing approaches cannot simultaneously achieve subcellular resolution, whol…
KUNGLIGA TEKNISKA HOEGSKOLAN
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