CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the mechanisms behind B cell immunoglobulin gene diversification, focusing on a specific regulatory sequence that activates hypermutation. The research aims to identify factors that interact with the enzyme Activation Induced cytidine Deaminase to better understand immune responses.
B cells distinguish themselves from all other cells, as they diversify their immunoglobulin (Ig) genes by hypermutation, gene conversion and switch recombination.
All three processes required the expression of Activation Induced cytidine Deaminase (AID).The project aims to resolve the long-standing question why hypermutations are targeted almost exclusively to the Ig loci.
Using the chicken B cell line DT40 as a model the fellow's laboratory previously identified a 10 kb cis-acting regulatory se…
UNIVERSITY OF GALWAY
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
