CORDIS Project
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This project aims to uncover the molecular mechanisms of regulatory T cells, which are vital for immune regulation. It focuses on the role of a specific protein, Tribbles-1, in T cell function and its implications for immunotherapy.
The role of regulatory T cells (Tregs) is crucial to maintain immune homeostasis by controlling peripheral tolerance. A better understanding in the molecular mechanisms involved in the biology of these Treg cells could improve their expansion and selection to treat immune-related diseases, achieve immunosuppression-free organ transplantation and to specifically target them in cancer.
We reported on the over-expression of Tribbles-1 (TRIB1) in Tregs compared to their counterpart naïve T cells and…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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