CORDIS Project
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This project investigates the role of PHD2, an oxygen sensor, in breast cancer metastasis. By studying its effects on tumor and stromal cells, it aims to uncover mechanisms that could lead to new therapeutic strategies for preventing cancer spread.
Breast cancer (BC) is the most frequently diagnosed cancer in women, affecting one in eight women.
Despite improved treatment strategies, BC recurrence after initial therapy is still responsible for nearly 500,000 deaths worldwide each year.
This is related to the fact that BC cells metastasize very early in the disease course, and often remain unnoticed at the time of diagnosis.
Novel therapeutic approaches that block metastasis offer thus great promise.
Hypoxia is a key characteristic of solid…
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