CORDIS Project
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This project investigates the BRCA2 gene's role in DNA repair and its implications for breast and ovarian cancer. It aims to uncover new protein interactions and develop therapeutic strategies using peptides to target tumor cells and block DNA repair pathways.
Mutations in the tumor suppressor gene, BRCA2, cause susceptibility to breast and ovarian cancer. BRCA2 protein is required for homologous recombinational DNA repair (HRR), the predominant mechanism employed by cells to accurately repair DNA double-stranded breaks (DSBs).
In humans, the central player of the HRR process is RAD51; it catalyzes the DNA strand exchange that results in the repaired DNA.
Through its interaction with RAD51, BRCA2 controls RAD51 function by locating it to the DSBs.
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