CORDIS Project
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This project investigates how Mycobacterium tuberculosis causes cell death in immune cells, focusing on a protein called Ninjurin-1. By studying the mechanisms of cell lysis and inflammation, the research aims to uncover new insights into tuberculosis pathology and potential therapeutic targets.
Mycobacterium tuberculosis (Mtb) causes tuberculosis a leading infectious killer worldwide.
Mtb primarily infects macrophages, leading to the death of some of these cells via distinct regulated cell death (RCD) mechanisms.
While apoptosis facilitates Mtb elimination, necrotic cell deaths, like pyroptosis, necroptosis, and ferroptosis may enhance bacterial replication and spread.
Mtb effectors, including the type VII secretion system ESX-1 and the cell wall lipid PDIM, induce host membrane damage…
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
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