CORDIS Project
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This project investigates the exclusion of heterogeneous nuclear ribonucleoproteins from damaged chromatin following DNA double-strand breaks. By employing advanced cellular models and genetic techniques, it aims to uncover the roles of RNAs and RNA-binding proteins in organizing the cellular response to DNA damage, wi…
DNA double-strand breaks (DSBs) are toxic lesions that must be efficiently repaired to maintain genome integrity.
Following DNA damage, cells activate a multi-layered signalling and repair network termed the DSB response.
Emerging organizers of this DSB response are various RNAs and RNA-binding proteins, which display characteristic localization dynamics at the damaged-chromatin.
The laboratory of Stephanie Panier recently showed that many heterogeneous nuclear ribonucleoproteins (hnRNPs) are ac…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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