CORDIS Project
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This project investigates the assembly and function of primary cilia in cells, focusing on the IntraFlagellar Transport complex. By reconstituting this complex from individual protein subunits, the research aims to enhance understanding of ciliary mechanisms and their roles in cellular processes.
Cilia are microtubule-based protrusions of the plasma membrane found on many eukaryotic cells, including most cell types of the human body.
Whereas the functions of motile cilia were immediately obvious, the role of the immotile or so-called primary cilia remained largely unrecognized for many decades.
Once referred to as aberrant solitary cilia with no obvious function, these ancient structures now hold the promise of revealing no less than the secrets of multicellularity and development.
Even…
TECHNISCHE UNIVERSITAET MUENCHEN
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