CORDIS Project
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The DISRUPT-KF project focuses on chronic kidney disease (CKD) by targeting myofibroblasts to prevent fibrosis and organ damage. It aims to validate novel inhibitors of GLI1/2 proteins as potential treatments to stabilize kidney function and reduce the progression of CKD.
Chronic kidney disease (CKD) is a progressive disease in which kidney function is gradually lost.
It can develop consequent of many (kidney) diseases and it affects more than 10% of the world population.
Although in recent years sodium–glucose cotransporter 2 inhibitors and novel non-steroidal mineralocorticoid antagonists are showing significant effects on CKD, the majority of patients treated still progress towards end-stage renal disease (ESRD).
With dialysis or kidney transplantation as the…
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