CORDIS Project
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This project investigates how DNA variations affect gene expression through regulatory elements like enhancers. By analyzing transcription factor binding and chromatin interactions, it aims to uncover the mechanisms linking genetic variation to gene expression changes, contributing to our understanding of gene regulati…
Numerous DNA variants have already been identified that modulate inter-individual molecular traits – most prominently gene expression.
However, since finding mechanistic interpretations relating genotype to phenotype has proven challenging, the focus has shifted to higher-order regulatory features, i.e. chromatin accessibility, transcription factor (TF) binding and 3D chromatin interactions.
This revealed at least two enhancer types: “lead” enhancers in which the presence of genetic variants mod…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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