CORDIS Project
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This project explores how condensin proteins facilitate the unlinking of sister DNA molecules during chromosome segregation. By studying bacterial models, it aims to clarify the mechanisms involved in chromosome organization and separation.
A prerequisite for chromosome segregation in all living organisms is the topological unlinking of sister DNA molecules, called DNA decatenation.
Decatenation is performed by DNA topoisomerases that work by transiently breaking strand(s) in one DNA double helix and passing another double helix through the temporarily created gate.
How DNA topoisomerases manage to recognize linkages between sister DNA molecules and how they promote decatenation of sister chromatids (but not catenation) is still la…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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