CORDIS Project
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This project investigates the mechanisms that maintain cell polarity in epithelial tissues under low-energy conditions, particularly focusing on the LKB1-AMPK signaling pathway. By using Drosophila as a model, it aims to identify new factors that regulate cell polarity during energy stress, which has implications for u…
Multicellularity requires the organization of cells into specialized tissues.
Cells that make up epithelial tissue are polarized; distinct outer (apical) and inner (basal) faces are central to their purpose.
Previous studies in animal and cell culture model systems have revealed a number of polarity determinants that act coordinately to establish and maintain epithelial cell polarity under normal conditions.
Recent work in Drosophila melanogaster has demonstrated that under starvation conditions…
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