CORDIS Project
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This project aims to develop a diagnostic platform to identify amino acid availability in cancer patients, which could guide dietary or therapeutic interventions. It builds on a method that assesses amino acid limitations in tumors.
Tumor growth requires continuous synthesis of proteins, nucleic acids and lipids that are important components of the cell.
Demand for amino acids as the building blocks for protein synthesis in rapidly dividing tumor cells is often much higher than that of normal cells.
Such increased demand can represent a vulnerability of the tumor.
Importantly, this vulnerability is already being exploited for therapy in one instance:
Addition of L-asparginase - an enzyme lowering the concentration of the am…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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