CORDIS Project
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This project aims to create new chemical reactions for constructing complex nitrogen-containing structures using asymmetric catalysis. By leveraging reactive intermediates, it seeks to develop a versatile method for synthesizing diverse organic compounds, including natural products.
We wish to develop new asymmetric Brønsted acid catalysed cyclisation reactions through direct condensation that will allow the efficient and highly enantioselective construction of azabicyclic and azaspirocyclic structures from readily available starting materials.
This will constitute a new, powerful and broadly applicable organocatalytic asymmetric strategy to such target molecules.
The concept of our proposal is to generate and exploit reactive N-acyl iminium ions in cyclisation reactions wh…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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