CORDIS Project
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This project focuses on enhancing the expression and stability of Class B G-protein coupled receptors (GPCRs) through directed evolution techniques. By optimizing these receptors, the aim is to facilitate their structural characterization, which is crucial for developing new drug therapies targeting various human disea…
Class B G-protein coupled receptors (GPCRs) are peptide hormone-binding receptors that are implicated in the pathogenesis several human diseases which makes them attractive targets for drug therapy.
To develop new compounds to target these receptors a detailed understanding of the molecular structure is required which has not been succeeded to date.
To elucidate the structure of proteins by X-ray crystallography or NMR spectroscopy large quantities of protein are required.
For GPCRs this prerequ…
University of Zurich
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