CORDIS Project
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This project focuses on creating synthetic models of natural membrane fusion processes to enable the direct delivery of molecules into living cells. By mimicking biological mechanisms, it aims to enhance applications in proteomics, genomics, and RNA technology, bypassing traditional cellular entry methods.
Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways.
This new paradigm opens many new applications in the fields of functional proteomics, ge…
UNIVERSITEIT LEIDEN
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