CORDIS Project
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The project explores the mechanisms behind long-lasting immune responses, focusing on plasma cells and memory B cells. By studying these cells in vaccinated individuals and patients with autoimmune diseases, it aims to uncover how they are selected and maintained over time.
Long term humoral immunity essentially relies on two types of cells exported from germinal centers (GC): plasma cells (PCs), which secrete antibodies, and memory B cells (MBCs).
Both subsets of cells can survive for decades in humans, being responsible for the extended protection afforded by the most successful vaccines but also therapeutic failures in the context of B-cell mediated autoimmune diseases.
Which cells are selected and what drives them to become long-lived, in normal or pathological…
UNIVERSITE PARIS XII VAL DE MARNE
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