CORDIS Project
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This project seeks to improve the selective functionalization of C-H bonds in organic molecules using transition metal catalysts. It focuses on using transient directing groups to enhance the synthesis of piperidine derivatives for drug discovery.
The transition metal-catalyzed direct functionalization of C-H bonds is a major research topic across the world.
However selective (regio-, enantio-, diastereoselective) and efficient functionalization of C(sp3)-H bonds, remains a significant challenge:
C(sp3)-H bonds are omnipresent in organic molecules and their dissociation energies are large.
The use of directing groups (DGs) “guiding” the metal to specific C-H bonds and allowing intramolecular C-H bond activation, is a recognized general ap…
UNIVERSITEIT ANTWERPEN
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