CORDIS Project
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This project aims to discover new natural products by utilizing genome mining and heterologous expression from unexplored bacterial sources. By expressing uncharacterized natural product gene clusters, it seeks to identify novel biochemistry and enhance the toolkit for natural product synthesis.
To overcome recent global health threats, such as antibiotic resistance, a resurgence in the discovery of new chemical and thus biomedical diversity from microbial sources is needed.
Genome mining in combination with heterologous expression is an approach that will overcome these challenges.
It involves incorporation of yet uncharacterized natural product genetic loci into a fast growing heterologous host.
For this approach, a prolific source of novel natural product gene clusters is vital.
Our…
TECHNISCHE UNIVERSITAET MUENCHEN
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