CORDIS Project
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This project focuses on understanding the role of the protein ISG15 in immune responses against bacterial infections. It aims to develop a method to identify ISG15 targets and analyze how ISGylation changes during Salmonella infection in macrophages, providing insights into immune defense mechanisms.
The protein interferon stimulated gene 15 (ISG15) is a highly conserved ubiquitin-like modifier important for innate immune responses in mammals. ISG15 is highly abundant in cell lysates and enriched on the phagosome of interferon-activated macrophages.
In humans, lack of ISG15 leads to increased susceptibility to infection by mycobacterial pathogens that reside in the phagosome of macrophages.
However, both ISGylation events and their role are poorly characterized.
This is partly due to the lac…
UNIVERSITY OF NEWCASTLE UPON TYNE
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