CORDIS Project
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DILITEST aims to develop a diagnostic test for Idiosyncratic Drug Induced Liver Injury (iDILI) using liver cell-like cells generated from blood samples. This innovative test seeks to prevent late-stage drug failures and ensure that patients have access to safe treatments.
Ca. 1 billion USD are lost by late stage failures per one successfully marketed drug.
Idiosyncratic Drug induced Liver injury (iDILI) is one of the major causes for late stage failures and also can have serious consequences for the patient like death or the need for liver transplantation. iDILI occurs only in susceptible patients regardless of drug dosage or latency and is not predictable from preclinical in vitro or animal testing.
Usually it occurs during late stage clinical phases, when hundr…
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