CORDIS Project
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This research investigates the organization and dynamics of chromatin in the human genome, focusing on how DNA packaging influences gene expression. The project aims to identify chromatin domains and their functional roles, particularly in relation to cancer, using computational analysis of large genomic datasets.
The human genome encodes for hundreds of transcriptional programs, which facilitates the unique functions and morphologies presented by different cell types.
Only recently, the role of DNA packaging into chromatin emerged as one of the major contributors to the modularity and dynamics of the genome.
Here, I propose to harness my computational expertise with vast amounts of publicly available data in mice and humans, and study the internal modularity and dynamics of genome packaging, and its rela…
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