CORDIS Project
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This project investigates the molecular mechanisms of Wnt signaling regulation through Dickkopf proteins and Kremen receptors. By reconstituting and analyzing protein complexes in vitro, the research aims to enhance understanding of how these proteins influence tissue development and homeostasis.
Orchestration of developmental processes as well as function and homeostasis of tissues depend on fine tuned intercellular communication, necessitating carefully controlled extracellular gradients of a wide range of signalling molecules.
Signalling by the Wnt family of secretory glycolipoproteins is renowned for its crucial roles in embryonic development and tissue homeostasis and is subject to a multi-layered system of regulation.
Conversely, dysregulation of Wnt signalling is implicated in dev…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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