CORDIS Project
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This project aims to develop a method for isolating brain-derived extracellular vesicles from the blood of migraine patients to identify specific biomarkers linked to migraine with aura. By characterizing these vesicles, the research seeks to enhance understanding of neuroinflammation and its role in migraines, potenti…
Migraine is a major disease burden on society but remains poorly understood.
The onset of migraine with aura has been linked to cortical spreading depolarisation (CSD) and Professor Turgay Dalkara (the supervisor) found that inducing CSD in animal models led neurons to release inflammatory proteins in extracellular vesicles (EVs).
Because brain-derived (BD)EVs cross the blood-brain barrier and their composition reflects their cellular and temporal origin, they represent biomarkers that, if isola…
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