CORDIS Project
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The project investigates the role of a specific bile acid, Ba1, in regulating fat cell formation and its potential as a treatment for obesity and type 2 diabetes. By assessing Ba1 and its analogs, the goal is to develop therapeutic options for metabolic disorders linked to obesity.
Within the past three years as part of the ERC funding, we have performed extensive research to identify novel factors that might influence adipogenesis and thus control development of obesity and associated metabolic disorders.
One of the factors we identified in a translational approach, was the transcription factor retinoic acid orphan receptor gamma (RORγ) which regulates fat cell formation in mice and humans. RORγ is considered as an orphan nuclear receptor as only weak natural ligands that…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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