CORDIS Project
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The DIAPREPP project investigates the early autoimmune processes leading to type 1 diabetes. By analyzing environmental and metabolic factors, it aims to uncover mechanisms of islet autoimmunization, potentially leading to better prediction and prevention strategies for the disease.
The earliest currently identifiable process in the pathogenesis of type 1 diabetes (T1D) is the development of autoimmunity to islet beta cells in the form of autoantibodies.
Hindering attempts to prevent autoimmune T1D, the aetiology and pathogenesis of the islet auto-immunization, including whether it is preceded by metabolic abnormalities and cell-mediated autoimmunity, is still poorly understood.
To overcome this, DIAPREPP will focus on the early auto-immunization against islet antigens, in…
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