CORDIS Project
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This project investigates the mechanisms behind insulin resistance in kidney cells related to diabetic nephropathy. It aims to develop animal models to study the role of specific proteins in podocytes and identify potential treatments for early-stage kidney disease.
Up to one third of diabetic patients develop nephropathy, a serious complication of diabetes.
Microalbuminuria is the earliest sign of the complication, which may ultimately develop to end-stage renal disease requiring dialysis or a kidney transplant.
Insulin resistance and metabolic syndrome are associated with an increased risk for diabetic nephropathy.
Interestingly, glomerular epithelial cells or podocytes have recently been shown to be insulin responsive.
Further, nephrin, a key structural…
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