CORDIS Project
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This project investigates the mechanisms behind axon loss in the nervous system, particularly during development and disease. It aims to uncover the cellular processes that lead to selective axon branch loss, which is crucial for understanding neurological disorders.
My aim is to explore the subcellular (i.e. cell biological and molecular) mechanisms of axon loss in the developing and diseased mammalian nervous system.
Axon loss not only sculpts neuronal networks in development, but also occurs early in numerous neurological diseases.
Indeed, the life-time risk for diseases with an “axonopathic” component approaches 50%.
Pathological axon loss likely involves aberrant activation of developmental programs – just as cell death in disease often takes the form o…
TECHNISCHE UNIVERSITAET MUENCHEN
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