CORDIS Project
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This project investigates the link between obesity, Type 2 diabetes, and increased cancer risk, focusing on mechanisms like hyperinsulinemia and hyperlipidemia. Using mouse models, it aims to understand how these metabolic disorders contribute to cancer development and metastasis, potentially leading to new therapeutic…
Epidemiological studies have clearly demonstrated that obesity and Type 2 diabetes are associated with an increased risk of developing common cancers including breast and colon cancer.
They are also associated with increased cancer related mortality.
While the mechanisms involved in this association are not yet defined, insulin resistance, hyperinsulinemia, hyperlipidemia, hyperglycemia and inflammatory cytokines are thought to be involved.Our studies, using separate mouse models of obesity or T…
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