CORDIS Project
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This research focuses on the role of specific RNA sequences in regulating protein synthesis during the early development of zebrafish embryos. By studying the translational control mechanisms, the project aims to uncover how these sequences influence embryonic development.
Following fertilisation, metazoan embryos are transcriptionally silent, and embryogenesis is controlled by maternally deposited factors.
Developmental progression requires the synthesis of new mRNAs and proteins in a coordinated fashion.
Many posttranscriptional mechanisms regulate the fate of maternal mRNAs, but it is less understood how translational control shapes early embryogenesis.
In eukaryotes, translation starts at the mRNA 5′ end, consisting of the 5′ cap and 5′ untranslated region (UT…
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