CORDIS Project
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This research focuses on understanding the role of microRNAs in the differentiation of T lymphocytes, which are crucial for immune responses. By creating a new mouse model, the project aims to explore how these small RNA molecules influence the balance between pro-inflammatory and regulatory immune cells in various dis…
T lymphocytes display potent pro- or anti-inflammatory properties, which typically associate with distinct effector (Teff) versus regulatory (Treg) cell subsets.
Based on published and our preliminary data showing a major impact of microRNAs on T cell differentiation and (auto)immune pathology, my proposal aims to dissect the miRNA networks that control the balance between Teff and Treg subsets in vivo, in various experimental models of infection and autoimmunity.
We will focus on three critica…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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