CORDIS Project
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This project investigates the spatial organization of the genome within cell nuclei and its impact on various nuclear processes. It employs a novel technique to study chromosome structure during early mouse development, aiming to enhance understanding of genome control.
The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation.
In fact, just about any nuclear/genome function has a spatial component that has been implicated in its control.
We know surprisingly little about chromosome conformation and spat…
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