CORDIS Project
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This project aims to develop small molecules that can restore the function of mutant p53, a key protein in cancer regulation. By using directed evolution techniques to identify compounds that stabilize p53, the research seeks to create potential therapeutics for various cancers.
Cancer imposes a tremendous socioeconomic burden in modern societies, causing ~1.7 million deaths in the EU annually. 15-20% of these cases occur due to mutations in the oncosuppressor gene p53, which destabilize the protein and inactivate its ability to mediate apoptosis under physiological conditions.
Today, no drugs exist which can restore the function of mutant p53 and treat cancer.
The present proposal deals with the discovery of potential cancer therapeutics of this type.
The topic of the…
NATIONAL HELLENIC RESEARCH FOUNDATION EIE NHRF
ETHNIKO IDRYMA EREVNON
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