CORDIS Project
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This project aims to manipulate enzyme specificity within a catalytic superfamily through directed evolution. By developing biochemical assays in small droplets, it seeks to enhance our understanding of enzyme kinetics and evolutionary relationships.
The ‘vastness of sequence space’, i.e. the extremely large number of possible permutations in even the smallest catalytic proteins, requires evolutionary shortcuts.
In this project the candidate will interconvert members of a promiscuous catalytic superfamily into one anotehr and differentiate a multi-specific enzyme into mono-specific mutants.
Ultimately it is hoped that directed evolution experiments will have implications for the definition of ‘phylogenetic relationships’ for catalysis.
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