CORDIS Project
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This project investigates cholangiopathies, diseases affecting bile duct cells, by developing a renewable source of cholangiocytes from human stem cells. It aims to create in vitro models for drug discovery and explore regenerative medicine applications.
Cholangiopathies represent a diverse group of diseases affecting cholangiocytes which are the main cell type of the biliary tract.
These disorders range from inherited (Cystic Fibrosis) and developmental (Alagille Syndrome, Biliary Atresia) to autoimmune (Primary Biliary Cirrhosis), idiopathic (Primary Sclerosing Cholangitis) and drug or toxin induced diseases.
Cholangiopathies result in toxic bile accumulation in the liver inducing cell death and ultimately cirrhosis.
They carry high morbidity…
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THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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