CORDIS Project
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This project investigates strategies to enhance the reconstitution of CD8 T lymphocytes, crucial for immune responses against pathogens. It focuses on understanding T cell development and memory generation, aiming to improve immune responses in conditions like cancer and chronic infections.
CD8 T lymphocytes have a fundamental role in ensuring the control of different types of intracellular pathogens including bacteria, parasites and most viruses.
This control may fail due to several reasons.
The current aggressive anti-cancer therapies (or rarely certain congenital immune deficiencies) induce CD8 depletion.
After bone-marrow transplantation, long time periods are required to ensure T cell reconstitution particularly in the adult.
This long lag-time is due to the long-time periods…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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