CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of specific gene mutations in motor neuron degeneration associated with Amyotrophic Lateral Sclerosis (ALS). It aims to develop animal models to understand the mechanisms of disease and screen for potential therapies using zebrafish as a model organism.
In 2008, I led a team that identified mutations in the TAR DNA binding protein (TARDBP) gene that encodes TDP-43 in ALS patients, which is enriched in inclusion bodies present in motor neurons from ALS patients.
Also, mutations in the fused in sarcoma (FUS) gene were identified in ALS patients, with FUS involved in similar molecular mechanisms as TDP-43.
This project aims to elucidate mechanisms involved in motor neuron degeneration caused by TDP-43 and FUS and to develop in vivo models to disco…
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
