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The project DevCycle investigates how cell divisions in developing intestinal tissues are timed and regulated in nematodes. By using advanced tools and a microfluidics platform, it aims to uncover the mechanisms behind cell-cycle gene expression changes and their impact on tissue architecture and organ size.
Animal development depends on precisely timed cell divisions, which ensure the formation of tissues and organs with specific architectures and functions.
As cells differentiate and mature, they need to modify the expression of cell-cycle regulators in order to achieve tissue-specific division patterns.
It is largely unknown how cells coordinate cell-cycle gene expression changes with developmental timing and how cell cycles can be altered to give rise to different tissue architectures and organ…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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