CORDIS Project
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This project investigates the emergence of distinct subpopulations in yeast that affect bioproduction efficiency. By utilizing advanced synthetic biology tools, it aims to develop engineered strains that eliminate low-producing cells, enhancing the yield of valuable molecules in both pure cultures and microbial communi…
Microbial bioproduction, despite being considered a paradigmatic sustainable alternative to petroleum-based chemistry, is often limited by low yields and productivities, which prevents commercialisation.
It is generally known for all types of cells that genetically identical populations can form metabolically distinct subpopulations.
This diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields.
However, the universal phenomenon of subp…
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