CORDIS Project
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This project seeks to create a three-dimensional hydrogel to support the regeneration of large bone defects using embryonic stem cells. By identifying key proteins that promote bone formation, it aims to develop a tailored hydrogel that enhances stem cell differentiation into bone-forming cells.
Regenerating large bone defects is a great challenge in regenerative medicine.
Embryonic stem cell (ESC) therapies are an attractive option due to their unlimited proliferation and ability to produce the cell types needed for bone repair.
Here, we propose creating a three-dimensional alginate hydrogel that displays bioactive epitopes and has mechanical properties that induce osteogenic differentiation of ESCs and increase bone formation in vitro.
We will do this by building upon previous rese…
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