CORDIS Project
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This project investigates the role of E-cadherin in cell adhesion and tissue integrity, particularly in response to environmental pollutants. It aims to understand how these pollutants may disrupt E-cadherin function and compromise epithelial tissue protection.
Cadherin expression on the surface of cells is critical for cell-cell adhesion and, consequently, for the development and the integrity of solid tissues.
In mammals, impaired cadherin mediated adhesion has been implicated in all steps of tumor progression. E-cadherin, a prominent member of the cadherin family, is expressed on the surface of epithelial cells in the digestive tract, in the lungs as well as in the testis and other organs and is therefore responsible for the integrity of the mucosal…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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