CORDIS Project
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This project focuses on developing new methods for the enantioselective synthesis of phosphorus-containing compounds, which are crucial in pharmaceuticals. By utilizing innovative superbase catalysts, the aim is to create chiral phosphates and phosphonates efficiently, enhancing their production for medical application…
Compounds containing one or more phosphorous atoms in the P(V) oxidation state are important to chemistry, biology and medicine.
These include marketed antiviral drugs such as Remdesivir, and Sofosbuvir; the former garnering interest as a potential treatment for COVID-19, and the latter being on the WHO list of essential medicines for the treatment of Hepatitis C.
Accordingly, new and improved methods for the efficient synthesis of P(V) containing compounds, especially in an enantioselective fas…
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