CORDIS Project
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The Destop project investigates how Neisseria meningitidis bacteria develop resistance to antibiotics during meningitis infections. By studying the mechanisms of vascular colonization, the project aims to uncover new strategies to combat bacterial meningitis and improve treatment efficacy for various bacterial infectio…
Before the antibiotic era chances of survival to bacterial meningitis were minimal.
Nevertheless, nearly 100 years later, surprisingly little progress has been made and mortality rates currently remain unacceptably high (10-25%).
Supported by clinical and experimental data, the central concept of the Destop project is that bacteria rapidly become insensitive to antibiotics during infection, which leads to treatment failure.
We hypothesize that the emergence of such antibiotic insensitivity resul…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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