CORDIS Project
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This project aims to design proteins that can specifically bind to nucleosomal DNA, which is crucial for regulating gene expression and has implications for cancer therapies. By combining computational design with experimental validation, the project seeks to create new strategies to block proteins that promote cancer.
DNA compresses in the cell by forming nucleosome particles, which diminish the accessibility of transcription factors to DNA and provide fine regulatory mechanisms for gene expression and replication.
Some proteins can still bind the exposed face of nucleosomal DNA and are known to promote cancer or viral infection, and strategies to block such binding events are promising for developing new epigenetic-like therapies.
However, structural information on proteins binding nucleosomal DNA is too lim…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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