CORDIS Project
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This project develops a novel system for protein evolution using a synthetic biology approach within E. coli. It aims to enhance protein properties for biotechnological applications by allowing for extensive mutation and selection processes in vivo.
Given our limited ability to rationally design proteins to our needs, their supply for biotechnological solutions leading to a sustainable Bioeconomy is relying on proteins found in nature and methods for deriving improved versions.
Proteins evolved their structure to fulfil certain functions in very specific niches, but these do not resemble optimal properties in the new context of biotechnological applications.
Hence, improving the activity, affinity and stability of a protein is key, but tech…
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